Monthly Archives: November 2013

New Publication: Flexible Gates Generate Occluded Intermediates in the Transport Cycle of LacY

In we examine how the , LacY, changes its structure to shuttle molecules of lactose across a cell membrane. The change in conformation is modelled usinga biased computational method called (DIMS) and the results compared to the results of some previously published . We conclude that LacY, as expected, does pass through an occluded intermediate and this is incompatible a simple rigid-body motion as implied by a “rocker-switch�? mechanism.

It is published in the and is  (open access).